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TP53 p.G245D Reference Standard

CBP10153

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Introduction 
Format Genomic DNA
Description TP53 G245D is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). G245D results in decreased activation of Tp53 target genes (PMID: 22214764, PMID: 25634208, PMID: 27533082), and also confers a gain-of-function to Tp53 as demonstrated by aberrant interaction with ZBP-89, as well as induction of FOXM1 expression, and leads to decreased apoptosis in culture and increased tumor growth and metastasis in mouse models (PMID: 22214764, PMID: 29269868).
   
Technical Data 
DNA Change: c.734G>A
AA Change p.G245D
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000269305
Cosmic ID COSM43606
Chr position(GRCh37) chr17:7577547
Buffer: Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing Download for COA
Storage 2-8℃
Expiry 36 months from the date of manufacture

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