hMUC17/4T1
CBPG0233
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產(chǎn)品描述
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| I. Background | |||
| MUC17 基因（染色體 7q22）編碼一種大型跨膜黏蛋白，屬于黏膜屏障核心組件。其 蛋白結(jié)構(gòu)包含信號肽、中央重復(fù)區(qū)（含可變數(shù)目串聯(lián)重復(fù)序列，VNTR）、兩個 EGF 樣結(jié) 構(gòu)域、SEA 模塊、跨膜域及含潛在磷酸化位點的胞質(zhì)尾區(qū)。這種設(shè)計使其兼具物理屏障與 信號調(diào)控功能：O-糖基化形成的黏液層直接抵御病原體（如腸侵襲性大腸桿菌）入侵，同 時通過 SEA 模塊參與蛋白酶解調(diào)控，維持腸道上皮動態(tài)平衡。 臨床研究揭示其雙重角色：在炎癥性腸?。ㄈ缈肆_恩?。┲?，MUC17 表達異常導(dǎo)致屏 障功能受損，增加感染風(fēng)險；而在胰腺癌中，MUC17 作為促癌因子，通過膽汁酸誘導(dǎo)加速 腫瘤進展，并與 MUC4 共表達，成為潛在預(yù)后標志物。 | |||
| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | hNUC17 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+ 10 μg/ml Puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
IV. Representative Data Figure1.Recombinant hMUC17/4T1 stably expressing hMUC17. |
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